Paper review on haematological malignancy Essay

Paper review on haematological malignancy - Essay ExampleOne of the cardinal enzymes of the pathways resulting in the production of prostaglandins is Cyclooxygenase-2 (cyclooxygenase-2) specifically in the tissue, which is being insulted, and either on the way to read to or has been transformed to a malignant tissue. Among these cancers, some common ones are lung, head and neck, ovarian, uterine cervix, colorectum, and breast. steady in the presence of high level of convincing data supporting the role of COX-2 in the progression of cancer, no definitive evidence is available which provides any clue to the relationship surrounded by COX-2 and haematological cancers.Myeloma (MM) is very well described as the deregulation of the cytokine net conk out accompanied by secretion of inflammatory cytokines. A train was carried out to look for the COX-2 deregulation in the pathogenesis of MM.For this purpose, a experiment of 142 pattern form 132 patients with plasma cell dyscrasias were taken and further tested for the expression of the proteins by horse opera Blot (WB) method. These patients were at different stages of the diseases as far as the advancement or severity was concerned. These specimen samples were taken after the informed consent from the patients were obtained. Clinical features of all the patients were documented. asunder from WB, real time Polymerase range of mountains Reaction (PCR) were as well carried out for some specimen. Along with these, COX-2 immunochemistry as well as separation of plasma cells was also performed. For statistical inferences, descriptive, univariate and multivariate analyses were done by using Cox model. Apart from the validation and assessment of MM samples and correlation between COX-2 expression and clinical parameters, the prognostic apprise of COX-2 expression in MM was also determined. It was found that median overall survival (OS) company up for the study participants was 48 months and the relationship betwee n COX-2 verifying and negative was (28 months vs 52 months) and it was significantly different. While Progression Free survival (PFS) was estimated as 18 months for positive and 36 months for negative patients and it was also significantly different. COX-2 was found to be related to MM as a prognostic cipher and it opened the venue for treatment options for MM as well as for more research work in the same and related areas to further explore any other associations. Significant contribution of the studyThe research work presented in this article is the first scientific report on the relationship between Cyclooxygenase-2 (COX-2) and Multiple Myeloma (MM). This is indeed an important finding, which adds to the available evidence on two facets 1) apart from fast tumor, COX-2 has got a relationship with haematological malignancies especially with multiple myeloma where it showed statistically significant association with sententious progression free period in COX-2 positive patients as compared to COX-2 negative patients (18 vs 36 months P .001) and at the same time poor overall survival in COX-2 positive